Pharmaceutical compound and process for making same



. Patented Mar. 25, 1930 um Eo STATES PAT ENT OFFICE WALTER T. WINCKLR,O1 CHICAGO, ILLINOIS, ASSIGNOB TO VON WINKLEB LABORA- I'ORIES,INCORPORATED, A CORPORATION 01 ILLINOIS PHABIAOEOTICAL COMPOUND ANDPROCESS FOR MAKING SAME Ho Drawing.

This invention relates to an improved pharmaceutical compound for thetreatment of germ diseases and particularly to a specific for gonorrhea.

The main objects of this invention are to provide an improved method formaking a pharmaceutical compound for employing chemically combinedsilver in a form which will resist decomposition, to provide an organiccompound containing, silver for the curing of acute and advanced statesof gonorrhea and healingtissue infected therewith, to provide apharmaceutical compound of the class described for preventing theconception of gonorrhea, to provide a soluble composition that willeffectively attack disease germs, especially gonococcus, and withoutcausing irritation or burning.

Heretofore silver has been used in various chemical combinations, suchas for example, silver albuminates, for the treatment of infections andgerm diseases, but great difiiculty has been encountered in obtaininsoluble compoundsof silver which are sta le, nonirritative when appliedto'animal membrane, and effective as gonococcus destroying agents.

I have found that when vegetable oils con- I taining fatty acids aresulphonated they provide organic 'chemical structures in which silver orother rare metals may be convenlently combined in such a manner as toproduce a compound that is stable, non-irritative, and effective as agerm-destroying agent. The silver, or other rare metal, is preferablyintroduced into the sulphonated vegetable oil in the form of an organicammonium structure.

= method of producing an improved compound of the class described, thefollowing ingredients are employed.

Four parts of castor oil are treated with one part of sulphuric acid, byweight, in any Application fled November 7, 1928. Serial No. 817,884.

Suflicient sodium hydroxide, preferably in,

solution form, is added to produce a product neutral to phenolphthalein.The sodium sulphate formed during the neutralizing step is precipitatedby dissolving the neutralized sulphoricin acid in aquantity of suitablesolvent, preferably alcohol substantially equal in weight to the castoroil originally used. The sodium sulphate precipitate is later removed byfiltration, leaving substantially chemically pure sulpho-ricin acid insolution.

Silver is then introduced into the compound by the addition of silverammonium formate to the sulpho-ricin acid, producing sulpho-ricin silverammonium formate.

- The quantity of silver ammonium formate required for the treatment of100 cubic centimeters of sulpho-ricin acid may be made by dissolving onegrain of silver nitrate in three and one-half cubic centimeters ofammonium hydroxide and adding formic acid thereto. Sufiicient formicacid is added to the silver solution, by the method of titration, torender it only slightly alkaline, the proper end point being indicatedby the occurrence of a slight change in color. The precipitation ofsilver formate is avoided by the presence of the ammonium hydroxide andthe slight alkalinity of the solution remaining after the addition, ofthe formic acid. The resulting sulphoricin silver ammonium formate whencompounded in the manner illustrated, contains substantially 1% silver,by weight.

The final sulpho-ricin silver compound has the characteristics ofstability, solubility, is non-irritating and highly effective fordestroying gonococcus. Since the absolute composition of castor oil isn'ot known, it is impossible to write a formula for the compound.

Although but one specific example of my invention has been hereindescribed, it will be understood that various changes in the details andsequence of steps of the process and substitutions of ingredients may bemade without departing from the spirit of this invention as defined bythe following claims:

I claim: 1. The method of preparing a pharmaceutical compound conslstingof sulphonating a fatt acid, introducing silver into chemical comination with the sulphonated fatty acid by the addition of silverammonium formate thereto.

2. The method of manufacturing a specific for gonorrhea consistin ofsulphonating ricin acid, and treating t e sul honate ricin acid withsilver ammonium ormate.

3. The methodof manufacturing a specific for gonorrhea consistingoftreating castor oil with sulphuric acid to form sulpho-ricin acid,neutralizing the latter with an alkali, dissolving the neutralizedsulpho-ricin acid in alcohol, and treating the alcohol solution with asolution containing silver to chemically combine the latter therewith.

4. The method of making a pharmaceutical compound consistin of treatingfour arts of castor oil with'su stantially one part, y weight, ofsulphuric acid, neutralizing the reaction product with sodium hydroxide,dissolving the neutralized product in alcohol, combinin silver with thealcohol solution by adding si ver ammonium 'formate thereto.

5. A specific for gonorrhea comprising sulpho-ricin silverammoniumformate.

Signed at Chicago this 31st 'day of October,

WALTER 'r. WINOKLER.

